Nicholas Edgington,    Biology

JOURNAL ARTICLES PUBLISHED:

 C.L. Thomas, M.J. Blacketer, N.P. Edgington, and A.M Myers:  Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p, and Cdc12p.  Yeast, Vol. 20, pp813-826, 2003.

 

N.P. Edgington and A.B. Futcher:  Relationship between the function and the location of G1 cyclins in S. cerevisiae. Journal of Cell Science,  Vol. 114(Pt 24), pp4599-4611, 2001.

 

N.P. Edgington, M.J. Blacketer, T.A. Bierwagen, and A.M. Myers:  Control of Saccharomyces cerevisiae filamentous growth by the cyclin-dependent kinase Cdc28p. Molecular and Cellular Biology, Vol.19, No.2, pp1369-1380, 1999.

 

A.L. Olson, N.P. Edgington, W.S. Moye-Rowley, and J.E. Pessin:  Characterization of 5Õ-heterogeneity of the rat  GLUT4/muscle-adipose glucose transporter gene product.  Endocrinology, Vol. 136, No. 5, pp 1962-1968, 1995.

 

M. Liu, A.L. Olson, N.P. Edgington, W.S. Moye-Rowley, and J.E. Pessin: Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/Muscle-adipose facilitative glucose transporter gene.  Journal of Biological Chemistry, Vol. 269, No. 45, pp 28514-28521, 1994.

 

J. Wemmie, A. Wu, N.P. Edgington, M. Goebl, J.L. Guevara and W.S. Moye-Rowley: Yeast bZip proteins mediate pleiotropic drug and metal resistance.  Journal of Biological Chemistry, Vol. 268, No. 25, pp 18850-18858, 1993.

N.P. Edgington, and S.W. Moye-Rowley: Rapid, high yield isolation of yeast mRNA.  Promega Notes , number 41, 3/4-1993. (Not a refereed journal)
 

CONFERENCE PAPERS DELIVERED:

 N.P. Edgington, B. Futcher:  DNA content, nuclear volume and cell volume in the control of Start. Yeast Cell Biology Meeting, Cold Spring Harbor Laboratory, New York, Abstract #72, (oral), 2003.

 

C. Thomas, M. Blacketer, N.P. Edgington, Alan Myers: Assembly interdependence among components of the bud neck control ring. Yeast Genetics and Molecular Biology Meeting, Seattle, Washington, Abstract #277, (poster), 2000.

 

N.P. Edgington and A.B. Futcher: Cyclin localization and function.  American Society for Cell Biology Annual Meeting, Washington, D.C., Abstract # 2507, (poster), 1999.

N.P. Edgington and A.B. Futcher:  Cyclin localization and function.  Cold Spring Harbor Laboratory Yeast Cell Biology Meeting, New York, Abstract # 269, (oral), 1999.

 

N.P. Edgington, M.J. Blacketer, and A.M. Myers:  Regulation of morphologic development in S. cerevisiae by a conserved protein kinase cascade that regulates CDK activity.  American Society for Cell Biology Annual Meeting/ Intl. Congress on Cell Biology, San Francisco, California, Abstract # 3001, (poster), 1996.

 

N.P. Edgington, and A. Myers:  Extragenic suppressor analysis of the protein kinase ELM1 identifies a dominant allele of a S. pombe nim1⁺ homologue in S. cerevisiae.  Yeast Genetics and Molecular Biology Meeting, Madison, Wisconsin, Abstract # 108B, (poster), 1996.

N.P. Edgington, and A. Myers:  Activation of cAMP-dependent protein kinase suppresses morphologic differentiation specifically in haploid Saccharomyces cerevisiae  strains.  Cold Spring Harbor Laboratory Yeast Cell Biology Meeting, Cold Spring Harbor, New York, Abstract # 105, (oral), 1995.

 

N.P. Edgington, and A. Myers:  Genetic analysis of morphologic differentiation of Saccharomyces cerevisiae.  Molecular Explorations Conference, Ames, Iowa, Abstract #5, (poster), 1995.

 

N.P. Edgington, M.J. Blacketer, P. Maduale, and A. Myers:  Genetic analysis of pseudohyphal differentiation in Saccharomyces cerevisiae .  Yeast Genetics and Molecular Biology Meeting, Seattle, Washington, Abstract #115A, (poster), 1994.

 

A.L. Olsen, N.P. Edgington, W.S. Moye-Rowley:  Characterization and transcriptional control of the rat GLUT4 gene in adipocytes.  Diabetes, 41(1): #319, (poster), 1992.

 

N.P. Edgington, J. Giordano, H. Swanson, and D.B. Stratton:  Thyroid state and response to 5-hydroxytryptamine in intact and denuded rat aortic rings., Journal of the Iowa Academy of Science, 97(1): A40, (oral), 1990.

 

N.P. Edgington, J. Giordano, and D.B. Stratton: Differential 5-HT receptor-mediated responses in aortic rings from thyro-pathologic rats., Society for Neuroscience , vol. 16(1): 357.9, (poster), 1990.
 

RECENT GRANTS RECEIVED:

2004      CSU research grant for research entitled, ÔInvestigation of Cyclin-dependent Kinase Control of Cell MorphogenesisÕ

SCSU Faculty Curriculum grant to prepare laboratory materials and exercises for the BIO436 (Cell Biology) course

RESEARCH INTERESTS IN GENERAL:

Kinases
Cell cycle
Morphogenesis
Cyclins
Signal transduction
Eukaryotic cell division
 

CURRENT/FUTURE SPECIFIC RESEARCH PROJECTS:

  I study the mechanisms by which the master regulators of the cell division cycle, the cyclin‑dependent kinases/cyclins, dictate cell shape during the cell cycle.
 

MASTER'S THESES ADVISEMENT:

2004    Second Reader for the Biology MasterÕs Thesis of Nicholas Beatty entitled ÔAn in situ hybridization study of the olfactory specific clone (OSC) mRNA of the olfactory rosette of Atlantic salmon.Õ

DISSERTATION TITLE:

 Dissertation Title:  Suppressor analysis of the protein kinase Elm1p, an enzyme involved in the regulation of yeast morphology.

INSTITUTION GRANTING Ph.D.:

Iowa State University       (1992-1997)    Ph.D.   Biochemistry & Molecular Biology
(Program in Molecular Cellular and Developmental Biology, Signal Transduction Training Group)