The Clinical Nurse Leader is a relatively new advanced practice role with preparation at the graduate level. Its focus is on managing complex cohorts of patients in a wide variety of health care settings. This 42-credit program consists of core courses (24 credits), two clinical courses (12 credits), and a thesis or special project component. Four hundred clinical hours of practice are required to meet practice requirements for certification as a Clinical Nurse Leader. These are spent exploring the structure and functioning of the macrosystem of a healthcare organization and analyzing its impact on the delivery of evidenced based nursing care to a specified group of patients. Prepared as an advanced practice generalist, the CNL is able to practice with any patient population and in most healthcare settings.