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Kelly Bordner

bordner

Associate Professor

Ph.D., Binghamton University, Binghamton, NY

email: bordnerk2@southernct.edu

phone: (203) 392-6862

 

Research Interests:

I use animal models to investigate important, yet hard-to study phenomenon. My research interests are centered under the overarching theme of development and focus on the consequences of early life experiences as they relate to changes in the brain and behavior. Currently, I have two lines of active research: Investigating the consequences of advancing paternal age on social behavior and neuroanatomical development of infant and adolescent rats, and the examination of behavioral and neuroanatomical changes following prenatal alcohol exposure.

Methods:

Behavioral techniques:

  • Conditioned place preference
  • Social approach
  • Social interaction
  • Intake tests
  • Open field
  • Novel object recognition
  • Delay discounting

Biochemical, Molecular, and histological techniques:

  • Western blotting
  • Bradford & Lowry protein assays
  • Transcardial perfusion
  • Immunohistochemistry

 

Research involving SCSU students (denoted with *):

*Bernatene, V., *Franco, J., *Ferens, E., *Konecy, M., *Pappas, J., * Squires, M. & Bordner, K. (2016). Effect of paternal age and obesity on GABAA receptor in the cerebellum of adolescent rats. Poster presented at the Undergraduate Research Conference, New Haven, CT.

 *Ferens, E., *Franco, J., *Bernatene, V., *Konecy, M., *Pappas, J., * Squires, M. & Bordner, K. (2016). Effects of paternal age and obesity on social behavior in adolescent rats. Poster presented at the Undergraduate Research Conference, New Haven, CT.

 *Battista, S., *Blue, K., *Curnane, M., *DiGaetano, B., *Flore, A., *Hernandez, S., *Joaquim, C., *LaBarre, B., *Neal, D., *Nicsaji, J., *Ramirez, D., *Toth, B., & Bordner, K. (2016). You made a good point! Individual differences associated with changing one's mind. Poster presented at the Undergraduate Research Conference, New Haven, CT.

*Ferens, E., *Vega, J., *Franco, J. & Bordner, K. (2015). When you fail to reject the null hypothesis: Methodological considerations for null results. Poster presented at the annual CSU Psychology Day, Danbury, CT.

*Santo, N. & Bordner, K. (2014). Paternal age as a potential factor in the development of autistic-like behavior in rats. Poster presented at the annual NEURON conferences, Hamden, CT.

*Santo, N., *Lahti, J. & Bordner, K. (2013). Immunohistochemistry protocol optimization: A methods experiment. Poster presented at the annual CSU Psychology day, New Britain, CT.

 

Publications:

Bordner, K., & Deak, T. (2015). Endogenous Opioids as Substrates for Ethanol Intake in the Neonatal Rat:  The impact of prenatal ethanol exposure on the opioid family in the early postnatal period. Physiology and Behavior, 148, 100-110.

 Doremus-Fitzwater, T. L., Buck, H. M., Bordner, K., Richey, L., Jones, M. E., & Deak, T. (2014). Intoxication- and withdrawal-dependent expression of central and peripheral cytokines following initial ethanol exposure. Alcoholism: Clinical and Experimental Research, 38(8), 2186-2198.

 Nizhnikov, M., Pautassi, R., Carter, J., Landin, J., Varlinskaya, E., Bordner, K., Werner, D. & Spear, N. (2014). Brief prenatal ethanol exposure alters behavioral sensitivity to the kappa opioid receptor agonist (U62,066E) and antagonist (Nor-BNI) and reduces kappa opioid receptor expression. Alcoholism, Clinical and Experimental Research, 38(6), 1630-1638.

 Carlyle, B. C., Nairn, A. C., Want, M., Yang, Y., Jin, L. E., Simen, A. A., Ramos, B. P., Bordner, K. A., Craft, G. E., Davies, P., Pletikos, M., Sestan, N., Arnsten, A. F. T. & Paspalas, C. D. (2014). cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proceedings of the National Academy of Sciences, 111(13), 5036-5041.

Carlyle, B. C., Duque, A., Kitchen, R. R., Bordner, K. A., Coman, D., *Doolittle, E., Papademetris, X., Hyder, F., Taylor, J. R., Simen, A. A. (2012). Maternal separation with early weaning: A rodent model providing novel insights into neglect associated developmental deficits. Developmental Psychopathology, 24(4), 1401-1416.

 Duque, A., Coman, D., Carlyle, B. C., Bordner, K. A., George, E. D., Papademetris, X., Hyder, F. & Simen, A. A. (2012). Neuroanatomical changes in a mouse model of early life neglect. Brain Structure and Function, 217(2), 459-472.

 Bordner, K. A., George, E. D., Carlyle, B., Duque, A., Kitchen, R., Lam, T., Colangelo, C., Stone, K., Abbott, T., Mane, S., Nairn, A. & Simen, A. A. (2011). Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect. Frontiers in Psychiatry, 2(18), 1-18.

 Bordner, K. A., Kitchen, R. R., George, E. D., Carlyle, B., Majahan, M. C., Mane, S. M., Taylor, J. R. & Simen, A. A. (2011). Parallel declines in cognition, motivation, and locomotion in aging mice: Associations with inflammation in the medial prefrontal cortex. Experimental Gerontology, 46(8),643-659.

 Simen, A. A., Bordner, K. A., Martin, M. P., Moy, L. & Barry, L. C. (2011). Cognitive dysfunction with aging and the role of inflammation. Therapeutic Advances in Chronic Disease, 2(3), 175-195.

 George, E.D., Bordner, K. A., Elwafi, H. M., & Simen, A. A. (2010). Maternal separation with early weaning: A novel mouse model of early life neglect. BMC Neuroscience, 11(123).

 Bordner, K. A., Molina, J. C. & Spear, N. E. (2008). Analysis of ethanol reinforcement in 1-day-old rats: Assessment through a brief and novel operant procedure. Alcoholism: Clinical and Experimental Research, 32(4), 580-592.

Bordner, K. A. & Spear, N. E. (2006). Olfactory learning in the 1-day old rat: Reinforcing effects of isoproterenol. Neurobiology of Learning and Memory.

 Bordner, K. A. & Spear, N. E. (2006). Trace conditioning in 1-day old rats. Developmental Psychobiology, 48, 58-70.

 Deak, T., *Bellamy, C. & Bordner, K. A. (2005). Protracted increases in core body temperature and interleukin-1 following acute administration of lipopolysaccaride: Implications for the stress response. Physiology and Behavior, 85, 296-307.

 Deak, T., *Bellamy, C., *D’Agostino, L. G., *Rosanoff, M., McElderry, N. K. & Bordner, K. A. (2005). Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide. BehaviouralBrain Research, 160, 125-134.

 Deak, T., Bordner, K. A., McElderry, N. K., Barnum, C. J. & Blandino Jr., P., Deak, M. M. & Tammariello, S. P. (2005). Stress-induced increases in hypothalamic IL-1: A systematic analysis of multiple stressor paradigms. Brain Research Bulletin, 64, 541-556.